A dynamic network of estrogen receptors in murine lymphocytes: fine-tuning the immune response.
Identifieur interne : 001D60 ( Main/Exploration ); précédent : 001D59; suivant : 001D61A dynamic network of estrogen receptors in murine lymphocytes: fine-tuning the immune response.
Auteurs : Andrea E. Schneider ; Eva Kárpáti ; Kitti Schuszter ; Eszter A. T Th ; Endre Kiss ; Margit Kulcsár [Hongrie] ; Gl Ria Lászl ; Janos Matko [Hongrie]Source :
- Journal of leukocyte biology [ 1938-3673 ] ; 2014.
Descripteurs français
- KwdFr :
- Activation des lymphocytes (immunologie), Animaux, Cartes d'interactions protéiques, Cycle oestral, Espace intracellulaire (métabolisme), Expression des gènes, Femelle, Hormones (métabolisme), Liaison aux protéines, Ligands, Membrane cellulaire (métabolisme), Mâle, Oestradiol (métabolisme), Production d'anticorps, Récepteur alpha des oestrogènes (métabolisme), Récepteur bêta des oestrogènes (métabolisme), Récepteurs couplés aux protéines G (métabolisme), Récepteurs des oestrogènes (génétique), Récepteurs des oestrogènes (métabolisme), Souris, Sous-populations de lymphocytes (immunologie), Sous-populations de lymphocytes (métabolisme), Transport de protéines.
- MESH :
- génétique : Récepteurs des oestrogènes.
- immunologie : Activation des lymphocytes, Sous-populations de lymphocytes.
- métabolisme : Espace intracellulaire, Hormones, Membrane cellulaire, Oestradiol, Récepteur alpha des oestrogènes, Récepteur bêta des oestrogènes, Récepteurs couplés aux protéines G, Récepteurs des oestrogènes, Sous-populations de lymphocytes.
- Animaux, Cartes d'interactions protéiques, Cycle oestral, Expression des gènes, Femelle, Liaison aux protéines, Ligands, Mâle, Production d'anticorps, Souris, Transport de protéines.
English descriptors
- KwdEn :
- Animals, Antibody Formation, Cell Membrane (metabolism), Estradiol (metabolism), Estrogen Receptor alpha (metabolism), Estrogen Receptor beta (metabolism), Estrous Cycle, Female, Gene Expression, Hormones (metabolism), Intracellular Space (metabolism), Ligands, Lymphocyte Activation (immunology), Lymphocyte Subsets (immunology), Lymphocyte Subsets (metabolism), Male, Mice, Protein Binding, Protein Interaction Maps, Protein Transport, Receptors, Estrogen (genetics), Receptors, Estrogen (metabolism), Receptors, G-Protein-Coupled (metabolism).
- MESH :
- chemical , genetics : Receptors, Estrogen.
- chemical , metabolism : Estradiol, Estrogen Receptor alpha, Estrogen Receptor beta, Hormones, Receptors, Estrogen, Receptors, G-Protein-Coupled.
- immunology : Lymphocyte Activation, Lymphocyte Subsets.
- metabolism : Cell Membrane, Intracellular Space, Lymphocyte Subsets.
- Animals, Antibody Formation, Estrous Cycle, Female, Gene Expression, Ligands, Male, Mice, Protein Binding, Protein Interaction Maps, Protein Transport.
Abstract
The actual level of circulating estrogen (17β-estradiol, E2) has a serious impact on regulation of diverse immune cell functions, where their classical cytoplasmic receptors, ERα and ERβ, act as nuclear transcriptional regulators of multiple target genes. There is growing evidence, however, for rapid, "non-nuclear" regulatory effects of E2 on lymphocytes. Such effects are likely mediated by putative membrane-associated receptor(s) (mER), but the mechanistic details and the involved signaling pathways still remained largely unknown because of their complexity. Here, we show that in lymphocytes, mERs can signalize themselves, and upon ligation, they are able to coordinate translocation of other E2Rs to the PM. Our data firmly imply existence of a complex, dynamic network of at least seven ER forms in murine lymphocytes: cytoplasmic and membrane-linked forms of ERα, ERβ, or GPR30 and a mER that can receive extracellular E2 signals. The latter mERs are likely palmitoylated, as they are enriched in lipid-raft microdomains, and their E2 binding is also cholesterol dependent. The data also support that ligation of mERs can induce rapid regulatory signals to lymphocytes and then internalize and let the E2 liberate in lysosomes. In addition, they can dynamically control the cell-surface linkage of other cytoplasmic ERs. As demonstrated by the differential effects of mER or cytoplasmic ER ligation on the proliferation of activated T and B lymphocytes, such a dynamic E2R network can be considered as a tool to manage accommodation/fine-tuning of lymphocytes to rapidly changing hormone levels.
DOI: 10.1189/jlb.2A0214-080RR
PubMed: 25070950
Affiliations:
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Schneider</name><affiliation><nlm:affiliation>Department of Immunology, Institute of Biology, Eotvos Lorand University, Budapest, Hungary; and.</nlm:affiliation><wicri:noCountry code="subField">Hungary; and</wicri:noCountry></affiliation></author><author><name sortKey="Karpati, Eva" sort="Karpati, Eva" uniqKey="Karpati E" first="Eva" last="Kárpáti">Eva Kárpáti</name><affiliation><nlm:affiliation>Department of Immunology, Institute of Biology, Eotvos Lorand University, Budapest, Hungary; and.</nlm:affiliation><wicri:noCountry code="subField">Hungary; and</wicri:noCountry></affiliation></author><author><name sortKey="Schuszter, Kitti" sort="Schuszter, Kitti" uniqKey="Schuszter K" first="Kitti" last="Schuszter">Kitti Schuszter</name><affiliation><nlm:affiliation>Department of Immunology, Institute of Biology, Eotvos Lorand University, Budapest, Hungary; and.</nlm:affiliation><wicri:noCountry code="subField">Hungary; and</wicri:noCountry></affiliation></author><author><name sortKey="T Th, Eszter A" sort="T Th, Eszter A" uniqKey="T Th E" first="Eszter A" last="T Th">Eszter A. T Th</name><affiliation><nlm:affiliation>Department of Immunology, Institute of Biology, Eotvos Lorand University, Budapest, Hungary; and.</nlm:affiliation><wicri:noCountry code="subField">Hungary; and</wicri:noCountry></affiliation></author><author><name sortKey="Kiss, Endre" sort="Kiss, Endre" uniqKey="Kiss E" first="Endre" last="Kiss">Endre Kiss</name><affiliation><nlm:affiliation>Department of Immunology, Institute of Biology, Eotvos Lorand University, Budapest, Hungary; and.</nlm:affiliation><wicri:noCountry code="subField">Hungary; and</wicri:noCountry></affiliation></author><author><name sortKey="Kulcsar, Margit" sort="Kulcsar, Margit" uniqKey="Kulcsar M" first="Margit" last="Kulcsár">Margit Kulcsár</name><affiliation wicri:level="3"><nlm:affiliation>Department of Obstetrics and Reproduction, Faculty of Veterinary Science, Szent Istvan University, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Obstetrics and 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Lorand University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author></analytic><series><title level="j">Journal of leukocyte biology</title><idno type="eISSN">1938-3673</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibody Formation</term><term>Cell Membrane (metabolism)</term><term>Estradiol (metabolism)</term><term>Estrogen Receptor alpha (metabolism)</term><term>Estrogen Receptor beta (metabolism)</term><term>Estrous Cycle</term><term>Female</term><term>Gene Expression</term><term>Hormones (metabolism)</term><term>Intracellular Space (metabolism)</term><term>Ligands</term><term>Lymphocyte Activation (immunology)</term><term>Lymphocyte Subsets (immunology)</term><term>Lymphocyte Subsets (metabolism)</term><term>Male</term><term>Mice</term><term>Protein Binding</term><term>Protein Interaction Maps</term><term>Protein Transport</term><term>Receptors, Estrogen (genetics)</term><term>Receptors, Estrogen (metabolism)</term><term>Receptors, G-Protein-Coupled (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes (immunologie)</term><term>Animaux</term><term>Cartes d'interactions protéiques</term><term>Cycle oestral</term><term>Espace intracellulaire (métabolisme)</term><term>Expression des gènes</term><term>Femelle</term><term>Hormones (métabolisme)</term><term>Liaison aux protéines</term><term>Ligands</term><term>Membrane cellulaire (métabolisme)</term><term>Mâle</term><term>Oestradiol (métabolisme)</term><term>Production d'anticorps</term><term>Récepteur alpha des oestrogènes (métabolisme)</term><term>Récepteur bêta des oestrogènes (métabolisme)</term><term>Récepteurs couplés aux protéines G (métabolisme)</term><term>Récepteurs des oestrogènes (génétique)</term><term>Récepteurs des oestrogènes (métabolisme)</term><term>Souris</term><term>Sous-populations de lymphocytes (immunologie)</term><term>Sous-populations de lymphocytes (métabolisme)</term><term>Transport de protéines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptors, Estrogen</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Estradiol</term><term>Estrogen Receptor alpha</term><term>Estrogen Receptor beta</term><term>Hormones</term><term>Receptors, Estrogen</term><term>Receptors, G-Protein-Coupled</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Récepteurs des oestrogènes</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Activation des lymphocytes</term><term>Sous-populations de lymphocytes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Lymphocyte Activation</term><term>Lymphocyte Subsets</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Membrane</term><term>Intracellular Space</term><term>Lymphocyte Subsets</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Espace intracellulaire</term><term>Hormones</term><term>Membrane cellulaire</term><term>Oestradiol</term><term>Récepteur alpha des oestrogènes</term><term>Récepteur bêta des oestrogènes</term><term>Récepteurs couplés aux protéines G</term><term>Récepteurs des oestrogènes</term><term>Sous-populations de lymphocytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Antibody Formation</term><term>Estrous Cycle</term><term>Female</term><term>Gene Expression</term><term>Ligands</term><term>Male</term><term>Mice</term><term>Protein Binding</term><term>Protein Interaction Maps</term><term>Protein Transport</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cartes d'interactions protéiques</term><term>Cycle oestral</term><term>Expression des gènes</term><term>Femelle</term><term>Liaison aux protéines</term><term>Ligands</term><term>Mâle</term><term>Production d'anticorps</term><term>Souris</term><term>Transport de protéines</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The actual level of circulating estrogen (17β-estradiol, E2) has a serious impact on regulation of diverse immune cell functions, where their classical cytoplasmic receptors, ERα and ERβ, act as nuclear transcriptional regulators of multiple target genes. There is growing evidence, however, for rapid, "non-nuclear" regulatory effects of E2 on lymphocytes. Such effects are likely mediated by putative membrane-associated receptor(s) (mER), but the mechanistic details and the involved signaling pathways still remained largely unknown because of their complexity. Here, we show that in lymphocytes, mERs can signalize themselves, and upon ligation, they are able to coordinate translocation of other E2Rs to the PM. Our data firmly imply existence of a complex, dynamic network of at least seven ER forms in murine lymphocytes: cytoplasmic and membrane-linked forms of ERα, ERβ, or GPR30 and a mER that can receive extracellular E2 signals. The latter mERs are likely palmitoylated, as they are enriched in lipid-raft microdomains, and their E2 binding is also cholesterol dependent. The data also support that ligation of mERs can induce rapid regulatory signals to lymphocytes and then internalize and let the E2 liberate in lysosomes. In addition, they can dynamically control the cell-surface linkage of other cytoplasmic ERs. As demonstrated by the differential effects of mER or cytoplasmic ER ligation on the proliferation of activated T and B lymphocytes, such a dynamic E2R network can be considered as a tool to manage accommodation/fine-tuning of lymphocytes to rapidly changing hormone levels.</div></front></TEI><affiliations><list><country><li>Hongrie</li></country><region><li>Hongrie centrale</li></region><settlement><li>Budapest</li></settlement></list><tree><noCountry><name sortKey="Karpati, Eva" sort="Karpati, Eva" uniqKey="Karpati E" first="Eva" last="Kárpáti">Eva Kárpáti</name><name sortKey="Kiss, Endre" sort="Kiss, Endre" uniqKey="Kiss E" first="Endre" last="Kiss">Endre Kiss</name><name sortKey="Laszl, Gl Ria" sort="Laszl, Gl Ria" uniqKey="Laszl G" first="Gl Ria" last="Lászl">Gl Ria Lászl</name><name sortKey="Schneider, Andrea E" sort="Schneider, Andrea E" uniqKey="Schneider A" first="Andrea E" last="Schneider">Andrea E. Schneider</name><name sortKey="Schuszter, Kitti" sort="Schuszter, Kitti" uniqKey="Schuszter K" first="Kitti" last="Schuszter">Kitti Schuszter</name><name sortKey="T Th, Eszter A" sort="T Th, Eszter A" uniqKey="T Th E" first="Eszter A" last="T Th">Eszter A. T Th</name></noCountry><country name="Hongrie"><region name="Hongrie centrale"><name sortKey="Kulcsar, Margit" sort="Kulcsar, Margit" uniqKey="Kulcsar M" first="Margit" last="Kulcsár">Margit Kulcsár</name></region><name sortKey="Matko, Janos" sort="Matko, Janos" uniqKey="Matko J" first="Janos" last="Matko">Janos Matko</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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